Vol 2-2 Original Research Article

Evaluation of the Therapeutic Effect of Patching in Intermittent Exotropia

Rimsha Sarosh1*, Omar Rashid2, Parsa Sarosh3

1Consultant, Paediatric Ophthalmology and Strabismus, MBBS, MS, FPOS. Dr Manzoor Eye Care Centre,28-Wazir Bagh, Srinagar, Jammu and Kashmir,190008.

2Consultant, Cornea and Refractive Surgery, MBBS, MS, FCRS, Dr Manzoor Eye Care Center, 28, Wazir Bagh, Srinagar, Jammu and Kashmir, India- 190010.

3PhD scholar, B-TECH, MSc Electronics. Department of Electronics and Instrumentation Technology, University of Kashmir, Hazratbal, Srinagar, Jammu and Kashmir, India -190006.

Purpose: To assess the therapeutic significance of patching, in patients of intermittent exotropia in relation to control of deviation, absolute measurements and stereopsis.

Material and Methods: This prospective study was carried out in the Strabismus and Paediatric ophthalmology clinic of a tertiary care hospital. Seventeen patients underwent patching of the dominant eye or alternate occlusion in case of no ocular preference, for a duration of 6 hours / day. Objective Prism cover test measurements, stereopsis evaluation and three point control of deviation scoring were done before and after the 6 months duration. Paired samples t test and Stuart-Maxwell marginal homogeneity test were employed for analysis.

Results: The mean near and distance deviation was 20.35 +/- 4.663 S.D and 21.18+/- 6.885 S.D improving to 13.82 +/- 5.065 S.D and 19.49+/- 5.478 S.D respectively (p<0.001). Angle of strabismus showed a positive trend and decline for near as well as distance measurements with conversion of exotropia subtypes into pseudo divergence excess. Improvement in stereopsis was noted with fine stereopsis of 60 sec seen in 14 patients (82.35%) post patching as against 9 patients (52.94%) before starting the treatment.(p=0.03). Control grading showed a significant improvement with 11 patients (64.70%) attaining a score of 1, whereas before the start of patching the majority i.e 10 patients (58.82%) had a control score of 3.(p=0.004)

Conclusion: Patching induces improvement in degree of control, stereopsis and reduction in angle of deviation.

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Vol 2-2 Mini Review Article

Alkylphosphocholines and Quaternary Ammonium Compounds against Acanthamoeba Keratitis

Ronnie Mooney*, Roderick Williams

Institute of Biomedical and Environmental Health Research, University of the West of Scotland, School of Health and Life Sciences, High Street, Paisley, PA1 2BE, Scotland, UK

Acanthamoeba keratitis (AK) is a sight threatening infection caused by the free-living amoeba Acanthamoeba. This infection is largely associated with contact lens wear and the recent increase in AK incidences highlights the ineffectiveness of existing curative and preventative treatments. Current curative and protective treatments being active in part, only against the infective trophozoites and often inducing their conversion to the protective cysts is a major issue, particularly when the latter are the main cause of disease resurgences and relapses. These point to the need for the discovery of new drugs for curative and preventive treatments. Two structurally similar chemical classes, alkylphosphocholines (APCs) and quaternary ammonium compounds (QACs) that address these issues will be discussed in this review.

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Vol 3-1 Mini Review Article

Hot Topics in Limbal Stem Cells Culture: Mini Review

Dina Javid1*, Jie Zhang2, Daryoush Hamidi Alamdari3

1Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

2Department of Ophthalmology, New Zealand National Eye Centre, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand

3Surgical Oncology Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

One of the most effective treatments for Limbal Stem Cells Deficiency (LSCD) is Cultivated Limbal Epithelial Stem Cells (CLET). Precise knowledge of limbal stem cells culture increase the quality of treatment, mitigate the side effects and complications of organ transplantation, and expedite the treatment process. However, protocols for CLET need further optimization and standardization. This mini review covers basic concepts and important criteria that should be taken into consideration in designing a successful CLET that can be helpful for other targets of regenerative medicine.

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